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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Recreating the specific biological features of platelets by mimicking the structure of the platelet ortranslocating the platelet membrane to synthetic particles holds great promise in disease treatment.This review highlights recent advancements made in the platelet-mimicking strategies.

Keywords： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: understanding of the role of platelets in cancer progression and metastasis provides promising approaches for plateletbiomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatmentThis review highlights recent progresses in platelet membrane-based drug delivery and unique strategies

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 276-279 doi: 10.1007/s11705-014-1426-x

Abstract: The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze ourabilities, and design the future technologies that will propel us to achieve the next level of drug deliveryEffective drug delivery systems can be developed by overcoming formulation barriers and/or biologicalThe third generation (3G) drug delivery systems will have to focus on understanding the biological barriersso that they can be overcome by engineering manipulation of the drug delivery systems.

Keywords： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: This review provides valuable information for the future development of probes and nano-delivery systems

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 496-507 doi: 10.1007/s11705-013-1362-1

Abstract: In principal and practice, only the application of an appropriately designed drug delivery system (DDS) is able to overcome such limitations, and yet the cost of developing a novel drug delivery system issystems in this century.systems.systems for these bio-macromolecular drugs, thereby realizing their clinical potential.

Keywords： delivery systems     bio-macromolecular drugs     cell penetrating peptides    

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Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 416-428 doi: 10.1007/s11684-021-0838-5

Abstract: of megakaryopoiesis, we speculate that abivertinib can affect megakaryocyte (MK) differentiation and plateletobserved megakaryopoiesis to determine the biological effect of abivertinib on MK differentiation and plateletWe also demonstrated in vivo that abivertinib decreased the number of MKs in bone marrow and plateletthese preclinical data collectively suggested that abivertinib could inhibit MK differentiation and platelet

Keywords： abivertinib     Btk inhibitor     platelet     megakaryocyte     megakaryopoiesis     thrombopoiesis    

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Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

Isabel Andia, Michele Abate

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 139-152 doi: 10.1007/s11684-017-0551-6

Abstract: Platelet-rich plasma therapies have emerged as a potential approach to enhance tissue repair and regenerationleukocytes at injured/pathological tissues mimicking the initial stages of healing.However, the efficacy of platelet-rich plasma is controversial in chronic diseases because patients&rsquoIn this review, the interactions between platelet-rich plasma and healing mechanisms were addressed andThe development of combinational platelet-rich plasma treatments that can be used safely and effectively

Keywords： regenerative medicine     joint conditions     muscle injuries     platelet rich plasma     tendinopathy     healing mechanisms    

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The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: of anti-β2GP I antibodies in complexes with β2GP I as mediators of plateletinvolvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in plateletPlatelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression andResults showed that the anti-β2GP I /β2GP I complex induced platelet

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy- -PMA). Various grades of Psy- -PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 521-528 doi: 10.1007/s11705-017-1612-8

Abstract: The application of gene delivery materials has been mainly focused on mammalian cells while rarely extendedThis study therefore widens the utilities of helical polypeptide as a unique category of gene deliverymaterials, and may find their promising applications toward plant gene delivery.

Keywords： α-helical polypeptide     plant gene delivery     protoplast     intact leaves     transfection    

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug DeliverySystems

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:
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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

Keywords： bioorthogonal reaction     cancer therapy     metabolic glycoengineering     bioorthogonal catalytic patch    

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Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 473-480 doi: 10.1007/s11684-016-0479-

Abstract:

Aiming to control rising medical expenditures and help improve China’s healthcare systems, thisWe used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital locatedmodels to compare the mean medical expenditures between insured and uninsured women undergoing caesarean deliveryThese findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures

Keywords： maternity insurance scheme     financial incentive     caesarean delivery     medical expenditure     China    

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polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet

Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 188-196 doi: 10.1007/s11705-014-1414-1

Abstract: Poly(ethylene glycol) monoacrylate (PEGMA) is grafted onto polycarbonateurethane (PCU) surface via ultraviolet initiated photopolymerization. The hydroxyl groups of poly(PEGMA) on the surface react with one NCO group of isophorone diisocyanate (IPDI) and another NCO group of IPDI is then hydrolyzed to form amino terminal group, which is further grafted with phosphorylcholine glyceraldehyde to establish a biocompatible hydrophilic structure on the surface. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the successful grafting of both PEG and phosphorylcholine functional groups on the surface. The decrease of the water contact angle for the modified film is caused by synergic effect of PEG and phosphorylcholine, which both have the high hydrophilicity. Furthermore, the number of platelets adhered is relative low on the synergetically modified PCU film compared with the PCU film modified only by poly(PEGMA). Our synergic modification method using both PEG and phosphorylcholine may be applied in surface modification of blood-contacting biomaterials and some relevant devices.

Keywords： poly(ethylene glycol) monoacrylate     phosphorylcholine     polycarbonateurethane     surface modification     anti-platelet    

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Title Author Date Type Operation

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Journal Article

Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis

Journal Article

Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions

Isabel Andia, Michele Abate

Journal Article

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via two

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Journal Article

Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug DeliverySystems

Zhijian CHEN, Wei LI,

Journal Article

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Journal Article

Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Journal Article

polycarbonateurethane surface with poly(ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet

Jing YANG,Juan LV,Bin GAO,Li ZHANG,Dazhi YANG,Changcan SHI,Jintang GUO,Wenzhong LI,Yakai FENG

Journal Article